It is well established that the incidence of colorectal cancer is lower in populations with a high dietary fibre intake. Given their location within the intestinal crypts and their ability to respond to chemical stimulants within the lumen, EECs are a potential candidate for being contributors to this effect (Bingham et al. 2003). Indeed, free fatty acid receptors FFA 2 and 3 have been demonstrated to be expressed by L cells and act as receptors to SCFAs (Karaki & Kuwahara 2010). Cani et al. fed rats a diet supplemented with non-digestible carbohydrate oligofructose for 4 weeks and observed an increased number of L cells in the ascending colon compared with rats fed with a standard diet. EEC differentiation factors NGN3 and NeuroD were also found to be increased, suggesting a relationship between dietary carbohydrates and enteroendocrine differentiation (Cani et al. 2007).
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Designed for freestanding or built-in installation. Proper ventilation is required to maintain satisfactory cooling and overall performance. See instruction manual for proper installation requirements. 2ff7e9595c
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